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Interleukin-7 Compartmentalizes Its Receptor Signaling Complex to Initiate CD4 T Lymphocyte Response
Interleukin (IL)-7 is a central cytokine that controls homeostasis of the CD4 T lymphocyte pool. Here we show on human primary cells that IL-7 binds to preassembled receptors made up of proprietary chain IL-7Rα and the common chain γc shared with IL-2, -4, -9, -15, and -21 receptors. Upon IL-7 bindi...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2865298/ https://ncbi.nlm.nih.gov/pubmed/20167604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.104232 |
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