Interleukin-7 Compartmentalizes Its Receptor Signaling Complex to Initiate CD4 T Lymphocyte Response

Interleukin (IL)-7 is a central cytokine that controls homeostasis of the CD4 T lymphocyte pool. Here we show on human primary cells that IL-7 binds to preassembled receptors made up of proprietary chain IL-7Rα and the common chain γc shared with IL-2, -4, -9, -15, and -21 receptors. Upon IL-7 bindi...

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Autori principali: Rose, Thierry, Pillet, Anne-Hélène, Lavergne, Vincent, Tamarit, Blanche, Lenormand, Pascal, Rousselle, Jean-Claude, Namane, Abdelkader, Thèze, Jacques
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865298/
https://ncbi.nlm.nih.gov/pubmed/20167604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.104232
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