Membrane Microdomains and Cytoskeleton Organization Shape and Regulate the IL-7 Receptor Signalosome in Human CD4 T-cells

Interleukin (IL)-7 is the main homeostatic regulator of CD4 T-lymphocytes (helper) at both central and peripheral levels. Upon activation by IL-7, several signaling pathways, mainly JAK/STAT, PI3K/Akt and MAPK, induce the expression of genes involved in T-cell differentiation, activation, and prolif...

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Detalhes bibliográficos
Main Authors: Tamarit, Blanche, Bugault, Florence, Pillet, Anne-Hélène, Lavergne, Vincent, Bochet, Pascal, Garin, Nathalie, Schwarz, Ulf, Thèze, Jacques, Rose, Thierry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605687/
https://ncbi.nlm.nih.gov/pubmed/23329834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.449918
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