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Aggregation of α-synuclein is kinetically controlled by intramolecular diffusion
We hypothesize that the first step of aggregation of disordered proteins, such as α-synuclein, is controlled by the rate of backbone reconfiguration. When reconfiguration is fast, bimolecular association is not stable, but as reconfiguration slows, association is more stable and subsequent aggregati...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3289313/ https://ncbi.nlm.nih.gov/pubmed/22308332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109526109 |
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