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Effects of Mutations on the Reconfiguration Rate of α-Synuclein

It is still poorly understood why α-synuclein, the intrinsically disordered protein involved in Parkinson’s and other neurodegenerative diseases, is so prone to aggregation. Recent work has shown a correlation between the aggregation rate and the rate of diffusional reconfiguration by varying temper...

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Dades bibliogràfiques
Publicat a:J Phys Chem B
Autors principals: Acharya, Srabasti, Saha, Shreya, Ahmad, Basir, Lapidus, Lisa J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836914/
https://ncbi.nlm.nih.gov/pubmed/26572968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.5b10136
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