Total Synthesis of the α-Subunit of the Human Glycoprotein Hormones (hGPH): Toward Fully Synthetic Homogeneous Human Follicle-Stimulating Hormone (hFSH)

Described herein is the first total chemical synthesis of the unique α-subunit of the human glycoprotein hormone (α-hGPH). Unlike the biologically–derived glycoprotein hormones, which are isolated as highly complex mixtures of glycoforms, α-hGPH obtained by chemical synthesis contains discrete homog...

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Detalhes bibliográficos
Main Authors: Aussedat, Baptiste, Fasching, Bernhard, Johnston, Eric, Sane, Neeraj, Nagorny, Pavel, Danishefsky, Samuel J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288947/
https://ncbi.nlm.nih.gov/pubmed/22280541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2111459
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