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Toward Fully Synthetic Homogeneous β-Human Follicle-Stimulating Hormone (β-hFSH) with a Biantennary N-linked Dodecasaccharide. Synthesis of β-hFSH with Chitobiose Units at the Natural Linkage Sites

A highly convergent synthesis of the sialic acid rich biantennary N-linked glycan found in human glycoprotein hormones, and its use in the synthesis of a fragment derived from the β-domain of human Follicle-Stimulating Hormone (hFSH) are described. The synthesis highlights the use of the Sinaÿ radic...

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Detalhes bibliográficos
Main Authors: Nagorny, Pavel, Fasching, Bernhard, Li, Xuechen, Chen, Gong, Aussedat, Baptiste, Danishefsky, Samuel J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756579/
https://ncbi.nlm.nih.gov/pubmed/19341309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja809554x
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