Hypoglycosylated hFSH Has Greater Bioactivity Than Fully Glycosylated Recombinant hFSH in Human Granulosa Cells

CONTEXT: Previous studies suggest that aging in women is associated with a reduction in hypoglycosylated forms of FSH. OBJECTIVE: Experiments were performed to determine whether glycosylation of the FSHβ subunit modulates the biological activity of FSH in human granulosa cells. DESIGN AND SETTING: R...

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Bibliografske podrobnosti
izdano v:J Clin Endocrinol Metab
Main Authors: Jiang, Chao, Hou, Xiaoying, Wang, Cheng, May, Jeffrey V., Butnev, Viktor Y., Bousfield, George R., Davis, John S.
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2015
Teme:
Hot Topics in Translational Endocrinology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454802/
https://ncbi.nlm.nih.gov/pubmed/25915568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2015-1317
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