Hypo-glycosylated hFSH drives ovarian follicular development more efficiently than fully-glycosylated hFSH: enhanced transcription and PI3K and MAPK signaling

STUDY QUESTION: Does hypo-glycosylated human recombinant FSH (hFSH18/21) have greater in vivo bioactivity that drives follicle development in vivo compared to fully-glycosylated human recombinant FSH (hFSH24)? SUMMARY ANSWER: Compared with fully-glycosylated hFSH, hypo-glycosylated hFSH has greater...

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Detalhes bibliográficos
Publicado no:Hum Reprod
Main Authors: Hua, Guohua, George, Jitu W, Clark, Kendra L, Jonas, Kim C, Johnson, Gillian P, Southekal, Siddesh, Guda, Chittibabu, Hou, Xiaoying, Blum, Haley R, Eudy, James, Butnev, Viktor Y, Brown, Alan R, Katta, Sahithi, May, Jeffrey V, Bousfield, George R, Davis, John S
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213452/
https://ncbi.nlm.nih.gov/pubmed/34059912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/humrep/deab135
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