Hypo-glycosylated hFSH drives ovarian follicular development more efficiently than fully-glycosylated hFSH: enhanced transcription and PI3K and MAPK signaling

STUDY QUESTION: Does hypo-glycosylated human recombinant FSH (hFSH18/21) have greater in vivo bioactivity that drives follicle development in vivo compared to fully-glycosylated human recombinant FSH (hFSH24)? SUMMARY ANSWER: Compared with fully-glycosylated hFSH, hypo-glycosylated hFSH has greater...

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Pubblicato in:Hum Reprod
Autori principali: Hua, Guohua, George, Jitu W, Clark, Kendra L, Jonas, Kim C, Johnson, Gillian P, Southekal, Siddesh, Guda, Chittibabu, Hou, Xiaoying, Blum, Haley R, Eudy, James, Butnev, Viktor Y, Brown, Alan R, Katta, Sahithi, May, Jeffrey V, Bousfield, George R, Davis, John S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2021
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213452/
https://ncbi.nlm.nih.gov/pubmed/34059912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/humrep/deab135
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