Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice

In several models of aging, microglia become more inflammatory and reactive to immune challenges. For example, peripheral LPS injection causes exaggerated microglial activation associated with prolonged sickness and depressive-like behavior in aged BALB/c mice. Therefore, the purpose of this study w...

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Main Authors: Fenn, Ashley M., Henry, Christopher J., Huang, Yan, Dugan, Allison, Godbout, Jonathan P.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288757/
https://ncbi.nlm.nih.gov/pubmed/22024136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2011.10.003
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