IL-4 Signaling Drives a Unique Arginase(+)/IL-1β(+) Microglia Phenotype and Recruits Macrophages to the Inflammatory CNS: Consequences of Age-Related Deficits in IL-4Rα after Traumatic Spinal Cord Injury

Alternative activation of microglia/macrophages (M2a) by interleukin (IL)-4 is purported to support intrinsic growth and repair processes after CNS injury. Nonetheless, alternative activation of microglia is poorly understood in vivo, particularly in the context of inflammation, injury, and aging. H...

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Main Authors: Fenn, Ashley M., Hall, Jodie C.E., Gensel, John C., Popovich, Phillip G., Godbout, Jonathan P.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2014
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069360/
https://ncbi.nlm.nih.gov/pubmed/24966389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1146-14.2014
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