IL-4 Signaling Drives a Unique Arginase(+)/IL-1β(+) Microglia Phenotype and Recruits Macrophages to the Inflammatory CNS: Consequences of Age-Related Deficits in IL-4Rα after Traumatic Spinal Cord Injury

Alternative activation of microglia/macrophages (M2a) by interleukin (IL)-4 is purported to support intrinsic growth and repair processes after CNS injury. Nonetheless, alternative activation of microglia is poorly understood in vivo, particularly in the context of inflammation, injury, and aging. H...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fenn, Ashley M., Hall, Jodie C.E., Gensel, John C., Popovich, Phillip G., Godbout, Jonathan P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2014
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069360/
https://ncbi.nlm.nih.gov/pubmed/24966389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1146-14.2014
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