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Protracted downregulation of CX(3)CR1 on microglia of aged mice after lipopolysaccharide challenge

Fractalkine (CX(3)CL1) to fractalkine receptor (CX(3)CR1) interactions in the brain are involved in the modulation of microglial activation. Our recent findings indicate that there is microglial hyperactivity in the aged brain during an inflammatory challenge. The underlying cause of this amplified...

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Detalhes bibliográficos
Main Authors: Wynne, Angela M, Henry, Christopher J., Huang, Yan, Cleland, Anthony, Godbout, Jonathan P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939290/
https://ncbi.nlm.nih.gov/pubmed/20570721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2010.05.011
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