Protracted downregulation of CX(3)CR1 on microglia of aged mice after lipopolysaccharide challenge

Fractalkine (CX(3)CL1) to fractalkine receptor (CX(3)CR1) interactions in the brain are involved in the modulation of microglial activation. Our recent findings indicate that there is microglial hyperactivity in the aged brain during an inflammatory challenge. The underlying cause of this amplified...

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Bibliographische Detailangaben
Hauptverfasser: Wynne, Angela M, Henry, Christopher J., Huang, Yan, Cleland, Anthony, Godbout, Jonathan P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939290/
https://ncbi.nlm.nih.gov/pubmed/20570721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2010.05.011
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