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The Mechanism of HLA-DM Induced Peptide Exchange in the MHC class II Antigen Presentation Pathway

HLA-DM serves a critical function in the loading and editing of peptides on MHC class II molecules. Recent data showed that the interaction cycle between MHC class II molecules and HLA-DM is dependent on the occupancy state of the peptide binding groove. Empty MHC class II molecules form stable comp...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Schulze, Monika-Sarah E. D., Wucherpfennig, Kai W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288754/
https://ncbi.nlm.nih.gov/pubmed/22138314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2011.11.004
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