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NMR Detection of pH-Dependent Histidine-Water Proton Exchange Reveals the Conduction Mechanism of a Transmembrane Proton Channel

The acid-activated proton channel formed by the influenza M2 protein is important for the lifecycle of the virus. A single histidine (His), His37, in the transmembrane domain (M2TM) of the protein is responsible for pH activation and proton selectivity of the channel. Recent studies suggested three...

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Bibliografske podrobnosti
Main Authors: Hu, Fanghao, Schmidt-Rohr, Klaus, Hong, Mei
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288706/
https://ncbi.nlm.nih.gov/pubmed/21974716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2081185
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