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NMR Detection of pH-Dependent Histidine-Water Proton Exchange Reveals the Conduction Mechanism of a Transmembrane Proton Channel
The acid-activated proton channel formed by the influenza M2 protein is important for the lifecycle of the virus. A single histidine (His), His37, in the transmembrane domain (M2TM) of the protein is responsible for pH activation and proton selectivity of the channel. Recent studies suggested three...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3288706/ https://ncbi.nlm.nih.gov/pubmed/21974716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2081185 |
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