Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles

B.pertussis adenylate cyclase toxin (ACT) intoxicates cells by producing intracellular cAMP. B.pertussis outer membrane vesicles (OMV) contain ACT on their surface (OMV-ACT), but the properties of OMV-ACT were previously unknown. We found that B.pertussis in the lung from a fatal pertussis case cont...

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Hauptverfasser: Donato, Gina M., Goldsmith, Cynthia S., Paddock, Christopher D., Eby, Joshua C., Gray, Mary C., Hewlett, Erik L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288663/
https://ncbi.nlm.nih.gov/pubmed/22289177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.01.032
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