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Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14

Homozygous ataxic mice (ax(J)) express reduced levels of the deubiquitinating enzyme Usp14. They develop severe tremors by 2–3 wk of age, followed by hindlimb paralysis, and death by 6–8 wk. While changes in the ubiquitin proteasome system often result in the accumulation of ubiquitin protein aggreg...

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Detalhes bibliográficos
Main Authors: Bhattacharyya, Bula J., Wilson, Scott M., Jung, Hosung, Miller, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287356/
https://ncbi.nlm.nih.gov/pubmed/22075695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00326.2010
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