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Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14
Homozygous ataxic mice (ax(J)) express reduced levels of the deubiquitinating enzyme Usp14. They develop severe tremors by 2–3 wk of age, followed by hindlimb paralysis, and death by 6–8 wk. While changes in the ubiquitin proteasome system often result in the accumulation of ubiquitin protein aggreg...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3287356/ https://ncbi.nlm.nih.gov/pubmed/22075695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00326.2010 |
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