ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice

Chromosomal instability (CIN) in tumors is characterized by chromosomal abnormalities and an altered gene expression signature; however, the mechanism of CIN is poorly understood. CCND1 (which encodes cyclin D1) is overexpressed in human malignancies and has been shown to play a direct role in trans...

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Detalhes bibliográficos
Main Authors: Casimiro, Mathew C., Crosariol, Marco, Loro, Emanuele, Ertel, Adam, Yu, Zuoren, Dampier, William, Saria, Elizabeth A., Papanikolaou, Alex, Stanek, Timothy J., Li, Zhiping, Wang, Chenguang, Fortina, Paolo, Addya, Sankar, Tozeren, Aydin, Knudsen, Erik S., Arnold, Andrew, Pestell, Richard G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287228/
https://ncbi.nlm.nih.gov/pubmed/22307325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60256
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