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ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice
Chromosomal instability (CIN) in tumors is characterized by chromosomal abnormalities and an altered gene expression signature; however, the mechanism of CIN is poorly understood. CCND1 (which encodes cyclin D1) is overexpressed in human malignancies and has been shown to play a direct role in trans...
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| Autors principals: | , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3287228/ https://ncbi.nlm.nih.gov/pubmed/22307325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60256 |
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