ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice

Chromosomal instability (CIN) in tumors is characterized by chromosomal abnormalities and an altered gene expression signature; however, the mechanism of CIN is poorly understood. CCND1 (which encodes cyclin D1) is overexpressed in human malignancies and has been shown to play a direct role in trans...

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Bibliografiska uppgifter
Huvudupphovsmän: Casimiro, Mathew C., Crosariol, Marco, Loro, Emanuele, Ertel, Adam, Yu, Zuoren, Dampier, William, Saria, Elizabeth A., Papanikolaou, Alex, Stanek, Timothy J., Li, Zhiping, Wang, Chenguang, Fortina, Paolo, Addya, Sankar, Tozeren, Aydin, Knudsen, Erik S., Arnold, Andrew, Pestell, Richard G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287228/
https://ncbi.nlm.nih.gov/pubmed/22307325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60256
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