Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells

Mammalian RNAi machinery facilitating transcriptional gene silencing (TGS) is the RNA-induced transcriptional gene silencing-like (RITS-like) complex, comprising of Argonaute (Ago) and small interfering RNA (siRNA) components. We have previously demonstrated promoter-targeted siRNA induce TGS in hum...

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Detalhes bibliográficos
Main Authors: Ahlenstiel, Chantelle L., Lim, Heidi G. W., Cooper, David A., Ishida, Takaomi, Kelleher, Anthony D., Suzuki, Kazuo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287199/
https://ncbi.nlm.nih.gov/pubmed/22064859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr891
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