Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples

BACKGROUND: Duplication of chromosome 15q11-q13 (dup15q) accounts for approximately 3% of autism cases. Chromosome 15q11-q13 contains imprinted genes necessary for normal mammalian neurodevelopment controlled by a differentially methylated imprinting center (imprinting center of the Prader-Willi loc...

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Detalhes bibliográficos
Main Authors: Scoles, Haley A, Urraca, Nora, Chadwick, Samuel W, Reiter, Lawrence T, LaSalle, Janine M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287113/
https://ncbi.nlm.nih.gov/pubmed/22152151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-2392-2-19
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