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Down-regulation of lck mRNA by T cell activation involves transcriptional and post-transcriptional mechanisms.
The p56lck tyrosine kinase is most likely to be involved in signal transduction of T lymphocyte activation. After full activation through the TcR/CD3 complex lck mRNA is transiently down-modulated. This down-modulation was due to an early decrease of both transcription and stability of the lck mRNA....
Uloženo v:
| Vydáno v: | Nucleic Acids Res |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
1991
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| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC328705/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1832493/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/19.17.4655 |
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