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Down-regulation of lck mRNA by T cell activation involves transcriptional and post-transcriptional mechanisms.

The p56lck tyrosine kinase is most likely to be involved in signal transduction of T lymphocyte activation. After full activation through the TcR/CD3 complex lck mRNA is transiently down-modulated. This down-modulation was due to an early decrease of both transcription and stability of the lck mRNA....

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Detalhes bibliográficos
Main Authors: Paillard, F, Vaquero, C
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC328705/
https://ncbi.nlm.nih.gov/pubmed/1832493
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