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Down-regulation of lck mRNA by T cell activation involves transcriptional and post-transcriptional mechanisms.
The p56lck tyrosine kinase is most likely to be involved in signal transduction of T lymphocyte activation. After full activation through the TcR/CD3 complex lck mRNA is transiently down-modulated. This down-modulation was due to an early decrease of both transcription and stability of the lck mRNA....
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| Главные авторы: | , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
1991
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC328705/ https://ncbi.nlm.nih.gov/pubmed/1832493 |
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