Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling

We use an integrated approach to understand breast cancer heterogeneity by modeling mRNA, copy number alterations, microRNAs, and methylation in a pathway context utilizing the pathway recognition algorithm using data integration on genomic models (PARADIGM). We demonstrate that combining mRNA expre...

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Autors principals: Kristensen, Vessela N., Vaske, Charles J., Ursini-Siegel, Josie, Van Loo, Peter, Nordgard, Silje H., Sachidanandam, Ravi, Sørlie, Therese, Wärnberg, Fredrik, Haakensen, Vilde D., Helland, Åslaug, Naume, Bjørn, Perou, Charles M., Haussler, David, Troyanskaya, Olga G., Børresen-Dale, Anne-Lise
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Breast Cancer Special Feature
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286992/
https://ncbi.nlm.nih.gov/pubmed/21908711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108781108
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