Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

The endocrine hormone fibroblast growth factor 21 (FGF21) is a powerful modulator of glucose and lipid metabolism and a promising drug for type 2 diabetes. Here we identify FGF21 as a potent regulator of skeletal homeostasis. Both genetic and pharmacologic FGF21 gain of function lead to a striking d...

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Detalhes bibliográficos
Main Authors: Wei, Wei, Dutchak, Paul A., Wang, Xunde, Ding, Xunshan, Wang, Xueqian, Bookout, Angie L., Goetz, Regina, Mohammadi, Moosa, Gerard, Robert D., Dechow, Paul C., Mangelsdorf, David J., Kliewer, Steven A., Wan, Yihong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286969/
https://ncbi.nlm.nih.gov/pubmed/22315431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200797109
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