The disulfide isomerase ERp57 mediates platelet aggregation, hemostasis, and thrombosis

A close homologue to protein disulfide isomerase (PDI) called ERp57 forms disulfide bonds in glycoproteins in the endoplasmic reticulum and is expressed on the platelet surface. We generated 2 rabbit Abs to ERp57. One Ab strongly inhibited ERp57 in a functional assay and strongly inhibited platelet...

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Bibliographic Details
Main Authors: Wu, Yi, Ahmad, Syed S., Zhou, Junsong, Wang, Lu, Cully, Matthew P., Essex, David W.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Platelets and Thrombopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286349/
https://ncbi.nlm.nih.gov/pubmed/22207737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-360685
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