Blockade of prostaglandin E(2) signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells

Dendritic cell (DC) homeostasis, like all mature blood cells, is maintained via hierarchal generation from hematopoietic precursors; however, little is known about the regulatory mechanisms governing DC generation. Here, we show that prostaglandin E(2) (PGE(2)) is required for optimal Flt3 ligand–me...

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Autors principals: Singh, Pratibha, Hoggatt, Jonathan, Hu, Peirong, Speth, Jennifer M., Fukuda, Seiji, Breyer, Richard M., Pelus, Louis M.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286345/
https://ncbi.nlm.nih.gov/pubmed/22110249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-342428
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