Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival

Recent evidence suggests chronic myeloid leukemia (CML) stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated patients. We investigated whether CML stem cells, in a transgenic mouse model of CML-like disease or derived from patients, are dependent on...

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Detalhes bibliográficos
Main Authors: Hamilton, Ashley, Helgason, G. Vignir, Schemionek, Mirle, Zhang, Bin, Myssina, Svetlana, Allan, Elaine K., Nicolini, Franck E., Müller-Tidow, Carsten, Bhatia, Ravi, Brunton, Valerie G., Koschmieder, Steffen, Holyoake, Tessa L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286213/
https://ncbi.nlm.nih.gov/pubmed/22184410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-326843
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