Differential roles of STAT1 and STAT2 in the sensitivity of JAK2V617F- vs. BCR-ABL-positive cells to interferon alpha

Abstract Background Interferon alpha (IFNa) monotherapy is recommended as the standard therapy in polycythemia vera (PV) but not in chronic myeloid leukemia (CML). Here, we investigated the mechanisms of IFNa efficacy in JAK2V617F- vs. BCR-ABL-positive cells. Methods Gene expression microarrays and...

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Main Authors: Claudia Schubert, Manuel Allhoff, Stefan Tillmann, Tiago Maié, Ivan G. Costa, Daniel B. Lipka, Mirle Schemionek, Kristina Feldberg, Julian Baumeister, Tim H. Brümmendorf, Nicolas Chatain, Steffen Koschmieder
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-04-01
Colecção:Journal of Hematology & Oncology
Assuntos:
IFNa
BCR-ABL
JAK2V617F
MPN
Polycythemia vera
Chronic myeloid leukemia
Acesso em linha:http://link.springer.com/article/10.1186/s13045-019-0722-9
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