Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion

BACKGROUND: Somatic calreticulin (CALR), Janus kinase 2 (JAK2), and thrombopoietin receptor (MPL) mutations essentially show mutual exclusion in myeloproliferative neoplasms (MPN), suggesting that they activate common oncogenic pathways. Recent data have shown that MPL function is essential for CALR...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Han, Lijuan, Schubert, Claudia, Köhler, Johanna, Schemionek, Mirle, Isfort, Susanne, Brümmendorf, Tim H., Koschmieder, Steffen, Chatain, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894373/
https://ncbi.nlm.nih.gov/pubmed/27177927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0275-0
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