Dissecting Genomic Aberrations in Myeloproliferative Neoplasms by Multiplex-PCR and Next Generation Sequencing

In order to assess the feasibility of amplicon-based parallel next generation sequencing (NGS) for the diagnosis of myeloproliferative neoplasms (MPN), we investigated multiplex-PCR of 212 amplicons covering genomic mutational hotspots in 48 cancer-related genes. Samples from 64 patients with MPN an...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kirschner, Martin M. J., Schemionek, Mirle, Schubert, Claudia, Chatain, Nicolas, Sontag, Stephanie, Isfort, Susanne, Ortiz-Brüchle, Nadina, Schmitt, Karla, Krüger, Luisa, Zerres, Klaus, Zenke, Martin, Brümmendorf, Tim H., Koschmieder, Steffen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404337/
https://ncbi.nlm.nih.gov/pubmed/25894969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123476
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