Correlation of amyloid PET ligand florbetapir F 18 ((18)F-AV-45) binding with β-amyloid aggregation and neuritic plaque deposition in postmortem brain tissue

BACKGROUND: Florbetapir F 18 ((18)F-AV-45) is a positron emission tomography (PET) imaging ligand for the detection of amyloid aggregation associated with Alzheimer’s disease. Earlier data showed that florbetapir F 18 binds with high affinity to β-amyloid plaques in human brain homogenates (Kd = 3.7...

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Main Authors: Choi, Seok Rye, Schneider, Julie A., Bennett, David A., Beach, Thomas G., Bedell, Barry J., Zehntner, Simone P., Krautkramer, Michael, Kung, Hank F., Skovronsky, Daniel M., Hefti, Franz, Clark, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286131/
https://ncbi.nlm.nih.gov/pubmed/22354138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WAD.0b013e31821300bc
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