The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiation

Cyclin-dependent kinase 5 (Cdk5) has been identified as a determinant of sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors. Here, the consequences of its depletion on cell survival, PARP activity, the recruitment of base excision repair (BER) proteins to DNA damage sites, and overall DNA...

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Detalhes bibliográficos
Principais autores: Bolin, Celeste, Boudra, Mohammed-Tayyib, Fernet, Marie, Vaslin, Laurence, Pennaneach, Vincent, Zaremba, Tomasz, Biard, Denis, Cordelières, Fabrice P., Favaudon, Vincent, Mégnin-Chanet, Frédérique, Hall, Janet
Formato: Artigo
Idioma:Inglês
Publicado em: SP Birkhäuser Verlag Basel 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285760/
https://ncbi.nlm.nih.gov/pubmed/21922195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-011-0811-6
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