PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility

The consequences of PARP-1 disruption or inhibition on DNA single-strand break repair (SSBR) and radio-induced lethality were determined in synchronized, isogenic HeLa cells stably silenced or not for poly(ADP-ribose) polymerase-1 (PARP-1) (PARP-1(KD)) or XRCC1 (XRCC1(KD)). PARP-1 inhibition prevent...

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Detalhes bibliográficos
Main Authors: Godon, Camille, Cordelières, Fabrice P., Biard, Denis, Giocanti, Nicole, Mégnin-Chanet, Frédérique, Hall, Janet, Favaudon, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490739/
https://ncbi.nlm.nih.gov/pubmed/18603595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn403
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