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Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20

Toll-like receptor (TLR) signaling is linked to autophagy that facilitates elimination of intracellular pathogens. However, it is largely unknown whether autophagy controls TLR signaling. Here, we report that poly(I:C) stimulation induces selective autophagic degradation of the TLR adaptor molecule...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Inomata, Megumi, Niida, Shumpei, Shibata, Ken-ichiro, Into, Takeshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: SP Birkhäuser Verlag Basel 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285758/
https://ncbi.nlm.nih.gov/pubmed/21964925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-011-0819-y
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