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Conformational locking upon cooperative assembly of Notch transcription complexes
The Notch intracellular domain (NICD) forms a transcriptional activation complex with the DNA-binding factor CSL and a transcriptional co-activator of the Mastermind family (MAML). The "RAM" region of NICD recruits Notch to CSL, facilitating the binding of MAML at the interface between the...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3285698/ https://ncbi.nlm.nih.gov/pubmed/22325781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.12.011 |
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