Structural and Mechanistic Insights into Cooperative Assembly of Dimeric Notch Transcription Complexes

Ligand-induced proteolysis of Notch produces an intracellular effector domain that transduces essential signals by regulating target gene transcription. This function relies on formation of transcriptional activation complexes that include intracellular Notch, a Mastermind co-activator, and the CSL...

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Autori principali: Arnett, Kelly L., Hass, Matthew, McArthur, Debbie G., Ilagan, Ma. Xenia G., Aster, Jon C., Kopan, Raphael, Blacklow, Stephen C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024583/
https://ncbi.nlm.nih.gov/pubmed/20972443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1938
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