Conformational locking upon cooperative assembly of Notch transcription complexes

The Notch intracellular domain (NICD) forms a transcriptional activation complex with the DNA-binding factor CSL and a transcriptional co-activator of the Mastermind family (MAML). The "RAM" region of NICD recruits Notch to CSL, facilitating the binding of MAML at the interface between the...

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Bibliografiske detaljer
Main Authors: Choi, Sung Hee, Wales, Thomas E., Nam, Yunsun, O’Donovan, Daniel, Sliz, Piotr, Engen, John R., Blacklow, Stephen C.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285698/
https://ncbi.nlm.nih.gov/pubmed/22325781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.12.011
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