Identification by Virtual Screening and In Vitro Testing of Human DOPA Decarboxylase Inhibitors

Dopa decarboxylase (DDC), a pyridoxal 5′-phosphate (PLP) enzyme responsible for the biosynthesis of dopamine and serotonin, is involved in Parkinson's disease (PD). PD is a neurodegenerative disease mainly due to a progressive loss of dopamine-producing cells in the midbrain. Co-administration...

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Autores principales: Daidone, Frederick, Montioli, Riccardo, Paiardini, Alessandro, Cellini, Barbara, Macchiarulo, Antonio, Giardina, Giorgio, Bossa, Francesco, Borri Voltattorni, Carla
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285636/
https://ncbi.nlm.nih.gov/pubmed/22384042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031610
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