Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications

Human hepatic peroxisomal AGT (alanine:glyoxylate aminotransferase) is a PLP (pyridoxal 5′-phosphate)-dependent enzyme whose deficiency causes primary hyperoxaluria Type I, a rare autosomal recessive disorder. To acquire experimental evidence for the physiological function of AGT, the K(eq),(overall...

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Bibliographic Details
Main Authors: Cellini, Barbara, Bertoldi, Mariarita, Montioli, Riccardo, Paiardini, Alessandro, Borri Voltattorni, Carla
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2007
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2049084/
https://ncbi.nlm.nih.gov/pubmed/17696873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070637
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