Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases

DOPA decarboxylase, the dimeric enzyme responsible for the synthesis of neurotransmitters dopamine and serotonin, is involved in severe neurological diseases such as Parkinson disease, schizophrenia, and depression. Binding of the pyridoxal-5′-phosphate (PLP) cofactor to the apoenzyme is thought to...

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Main Authors: Giardina, Giorgio, Montioli, Riccardo, Gianni, Stefano, Cellini, Barbara, Paiardini, Alessandro, Voltattorni, Carla Borri, Cutruzzolà, Francesca
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251144/
https://ncbi.nlm.nih.gov/pubmed/22143761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111456108
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