Učitavanje...
Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases
DOPA decarboxylase, the dimeric enzyme responsible for the synthesis of neurotransmitters dopamine and serotonin, is involved in severe neurological diseases such as Parkinson disease, schizophrenia, and depression. Binding of the pyridoxal-5′-phosphate (PLP) cofactor to the apoenzyme is thought to...
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| Glavni autori: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3251144/ https://ncbi.nlm.nih.gov/pubmed/22143761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111456108 |
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