Characterization of Spindle Checkpoint Kinase Mps1 Reveals Domain with Functional and Structural Similarities to Tetratricopeptide Repeat Motifs of Bub1 and BubR1 Checkpoint Kinases

Kinetochore targeting of the mitotic kinases Bub1, BubR1, and Mps1 has been implicated in efficient execution of their functions in the spindle checkpoint, the self-monitoring system of the eukaryotic cell cycle that ensures chromosome segregation occurs with high fidelity. In all three kinases, kin...

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Bibliographische Detailangaben
Hauptverfasser: Lee, Semin, Thebault, Philippe, Freschi, Luca, Beaufils, Sylvie, Blundell, Tom L., Landry, Christian R., Bolanos-Garcia, Victor M., Elowe, Sabine
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285366/
https://ncbi.nlm.nih.gov/pubmed/22187426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.307355
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