Biochemically Defined HIV-1 Envelope Glycoprotein Variant Immunogens Display Differential Binding and Neutralizing Specificities to the CD4-binding Site

HIV-1 gp120 binds the primary receptor CD4. Recently, a plethora of broadly neutralizing antibodies to the gp120 CD4-binding site (CD4bs) validated this region as a target for immunogen design. Here, we asked if modified HIV-1 envelope glycoproteins (Env) designed to increase CD4 recognition might i...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Feng, Yu, McKee, Krisha, Tran, Karen, O'Dell, Sijy, Schmidt, Stephen D., Phogat, Adhuna, Forsell, Mattias N., Karlsson Hedestam, Gunilla B., Mascola, John R., Wyatt, Richard T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285340/
https://ncbi.nlm.nih.gov/pubmed/22167180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.317776
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky