Biochemically Defined HIV-1 Envelope Glycoprotein Variant Immunogens Display Differential Binding and Neutralizing Specificities to the CD4-binding Site

HIV-1 gp120 binds the primary receptor CD4. Recently, a plethora of broadly neutralizing antibodies to the gp120 CD4-binding site (CD4bs) validated this region as a target for immunogen design. Here, we asked if modified HIV-1 envelope glycoproteins (Env) designed to increase CD4 recognition might i...

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Detalhes bibliográficos
Main Authors: Feng, Yu, McKee, Krisha, Tran, Karen, O'Dell, Sijy, Schmidt, Stephen D., Phogat, Adhuna, Forsell, Mattias N., Karlsson Hedestam, Gunilla B., Mascola, John R., Wyatt, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285340/
https://ncbi.nlm.nih.gov/pubmed/22167180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.317776
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