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Unique Peptide Substrate Binding Properties of 110-kDa Heat-shock Protein (Hsp110) Determine Its Distinct Chaperone Activity

The molecular chaperone 70-kDa heat-shock proteins (Hsp70s) play essential roles in maintaining protein homeostasis. Hsp110, an Hsp70 homolog, is highly efficient in preventing protein aggregation but lacks the hallmark folding activity seen in Hsp70s. To understand the mechanistic differences betwe...

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Main Authors: Xu, Xinping, Sarbeng, Evans Boateng, Vorvis, Christina, Kumar, Divya Prasanna, Zhou, Lei, Liu, Qinglian
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285339/
https://ncbi.nlm.nih.gov/pubmed/22157767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.275057
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