Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons

Apolipoprotein E4 (apoE4), the major genetic risk factor for late onset Alzheimer disease, assumes a pathological conformation, intramolecular domain interaction. ApoE4 domain interaction mediates the detrimental effects of apoE4, including decreased mitochondrial cytochrome c oxidase subunit 1 leve...

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Main Authors: Chen, Hung-Kai, Liu, Zhaoping, Meyer-Franke, Anke, Brodbeck, Jens, Miranda, Rene D., McGuire, James G., Pleiss, Michael A., Ji, Zhong-Sheng, Balestra, Maureen E., Walker, David W., Xu, Qin, Jeong, Dah-eun, Budamagunta, Madhu S., Voss, John C., Freedman, Stephen B., Weisgraber, Karl H., Huang, Yadong, Mahley, Robert W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285306/
https://ncbi.nlm.nih.gov/pubmed/22158868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.276162
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