Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease

Apolipoprotein (apo) E4 is the major genetic risk factor for late-onset Alzheimer disease (AD). ApoE4 assumes a pathological conformation through an intramolecular interaction mediated by Arg-61 in the amino-terminal domain and Glu-255 in the carboxyl-terminal domain, referred to as apoE4 domain int...

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Detalhes bibliográficos
Main Authors: Chen, Hung-Kai, Ji, Zhong-Sheng, Dodson, Sara E., Miranda, Rene D., Rosenblum, Charles I., Reynolds, Ian J., Freedman, Stephen B., Weisgraber, Karl H., Huang, Yadong, Mahley, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037634/
https://ncbi.nlm.nih.gov/pubmed/21118811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.151084
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