Aberrant Cyclization Affords a C-6 Modified Cyclic Adenosine 5′-Diphosphoribose Analogue with Biological Activity in Jurkat T Cells

[Image: see text] Two nicotinamide adenine dinucleotide (NAD(+)) analogues modified at the 6 position of the purine ring were synthesized, and their substrate properties toward Aplysia californica ADP-ribosyl cyclase were investigated. 6-N-Methyl NAD(+) (6-N-methyl nicotinamide adenosine 5′-dinucleo...

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Bibliographische Detailangaben
Hauptverfasser: Moreau, Christelle, Kirchberger, Tanja, Zhang, Bo, Thomas, Mark P., Weber, Karin, Guse, Andreas H., Potter, Barry V. L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2012
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285147/
https://ncbi.nlm.nih.gov/pubmed/22248391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201127y
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